Design Principles for Nanoparticles Enveloped by a Polymer-Tethered Lipid Membrane
نویسندگان
چکیده
منابع مشابه
In vitro and in vivo mRNA delivery using lipid-enveloped pH-responsive polymer nanoparticles.
Biodegradable core--shell structured nanoparticles with a poly(β-amino ester) (PBAE) core enveloped by a phospholipid bilayer shell were developed for in vivo mRNA delivery with a view toward delivery of mRNA-based vaccines. The pH-responsive PBAE component was chosen to promote endosome disruption, while the lipid surface layer was selected to minimize toxicity of the polycation core. Messenge...
متن کاملDesigning polymer-tethered membrane-nanoparticle composites
This thesis proposes a novel design of nanoparticles for drug delivery. By tethering a bilayer membrane vesicle to a solid nanoparticle core at its center using hydrophilic soft polymers, this structure is expected to exhibit improved stability, narrowed size distribution, and a variety of functionalization possibilities. Various aspects of this design will be examined from a theoretical perspe...
متن کاملQuantifying lipid contents in enveloped virus particles with plasmonic nanoparticles.
Phosphatidylserine (PS) and monosialotetrahexosylganglioside (GM1 ) are examples of two host-derived lipids in the membrane of enveloped virus particles that are known to contribute to virus attachment, uptake, and ultimately dissemination. A quantitative characterization of their contribution to the functionality of the virus requires information about their relative concentrations in the vira...
متن کاملPhysisorbed Polymer-Tethered Lipid Bilayer with Lipopolymer Gradient
Physisorbed polymer-tethered lipid bilayers consisting of phospholipids and lipopolymers represent an attractive planar model membrane platform, in which bilayer fluidity and membrane elastic properties can be regulated through lipopolymer molar concentration. Herein we report a method for the fabrication of such a planar model membrane system with a lateral gradient of lipopolymer density. In ...
متن کاملCholesterol-Induced Buckling in Physisorbed Polymer-Tethered Lipid Monolayers
The influence of cholesterol concentration on the formation of buckling structures is studied in a physisorbed polymer-tethered lipid monolayer system using epifluorescence microscopy (EPI) and atomic force microscopy (AFM). The monolayer system, built using the Langmuir-Blodgett (LB) technique, consists of 3 mol % poly(ethylene glycol) (PEG) lipopolymers and various concentrations of the phosp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ACS Nano
سال: 2015
ISSN: 1936-0851,1936-086X
DOI: 10.1021/acsnano.5b03439